2007:Syllabus: readings, lecture/discussions, examinations.

        Laboratory syllabus: lab meetings, planned laboratory work, due dates for lab book grading.

 This project on yeast models of human genetic disease is based on analysis of current status of metabolic genes cited in this paper:

Francoise Foury, Human Gene Diseases: A Cross-Talk between Man and Yeast.  Gene 195 (1997):1-10.

 You can get this pdf from the PubMed database on the Library website.  A list of the most relevant metabolic genes from this paper, with yeast and human homologs, is here.  A list of the things you need to put on your web page about your human metabolic genetic disease gene and its yeast homolog can be found here. You can find out about the yeast genes here: http://www.yeastgenome.org/

You can find out about human genes by reading references in PubMed and by looking at OMIM: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM

Each student is constructing a page as shown below, in spring, 2006.  By late April, these pages will be complete; now they are under construction but may still be useful.  As soon as they are initiated, they will be linked to this main page for the course, so that potential users can visit them to see what information is currently posted there.  Our overall intention is to look at 8 genes to see if yeast has served as a model for human genetic diseases, or if human biochemistry has guided the yeast research.  In other words, is yeast serving as a model system for human genetic diseases or not? 

            Adenosine Deaminase enzyme, Jacqueline King

            Glucose 6 Phosphate Dehydrogenase enzyme, Caroline King

            Pyruvate Carboxylase enzyme, David McCormick

            Alpha Keto Glutarate Dehydrogenase enzyme, Mariko Yamazaki

            Pyruvate Kinase enzyme, Ellen Perkins

            Pyruvate Dehydrogenase enzyme, Allison Moser

            Fumarate Hydratase enzyme, Sarah Dumas

           Arginio Succinate Synthetase, Aaron Cooper

        Exam 1 review materials: Background 1,  Background 2, Energy, Glycolysis, TCA cycle, Electron Transport and Oxidative Phosphorylation,

            Associated pathways (through gluconeogenesis).

        Exam 2 review materials: Fatty acid metabolism  Other lipids

Description of laboratory work for 2006 on yeast diauxie and GFP Sch9 protein kinase, with and without analog sensitivity.

-  Lab Data Collection: Excel Worksheet