| Biology 189L Emerging Infectious Diseases |
Spring 2005 |
Schedule & Assignments
Please note that the assignments and schedule are still subject to change.
| Date | Topic | Reading | Assignment | Presenter |
| Wednesday, January 19 |
Introduction | -- | -- | Prof. Hamlett |
| Friday, January 21 |
Infectious Disease Hype? | Pinner, R. W. et al. 1996. Trends in infectious disease mortality in the United States. JAMA - Journal of the American Medical Association 275: 189-193. Garrett, Laurie. 1996. "Deadly rise of infections - Only heart disease and cancer kill more in the United States." Newsday, January 17. Statistical Assessment Service. 1996 "Don't catch infectious disease hype." (Available at http://www.stats.org/record.jsp?type=oped&ID=99.) |
Homework #1 [ERes] | Class discussion |
| Monday, January 24 |
Structure of Bacterial Pathogens | Bacterial Pathogenesis - Ch. 1 | E-mail Prof. H your disease choices! | Prof. Hamlett |
| Wednesday, January 26 |
Virulence Factors in Bacteria | Bacterial Pathogenesis - Ch. 8 & 9 | Homework #2 [ERes] | Prof. Hamlett |
| Friday, January 28 |
Genetic Control of Virulence Factors | Goodman, A. L., B. Kulasekara, A. Rietsch, D. Boyd, R. S. Smith, and S. Lory. A signaling network reciprocally regulates genes associated with acute infection and chronic persistence in Pseudomonas aeruginosa. 2004. Dev. Cell 7: 745-754. [ERes] For background, refer to Ch. 16 - "Pseudomonas aeruginosa and Related Species", in Bacterial Pathogenesis, and to "Jekyll or hide?" by George O'Toole, Nature 432: 680-681 (News & Views article) [html | pdf] |
Paper Analysis [MS Word] | Class discussion |
| Monday, January 31 |
Viral pathogens | Introductory virus chapters from Microbiology Online, University of South Carolina School of Medicine:
|
Final version of Paper Analysis [MS Word] for Goodman et al. | Prof. Hamlett |
| Wednesday, February 2 |
Viral pathogens (cont.) | No new reading | HW#3 - Structure of your pathogen [ERes] | Prof. Hamlett |
| Friday, February 4 |
A new virus in children | Esper, F., C. Weibel, D. Ferguson, M. L. Landry, and J. S. Kahn. 2005. Evidence of a novel human coronavirus that Is associated with respiratory tract disease in infants and young children. J. Inf. Dis. 191(4): 492-498. [html | pdf] Esper, F., E, D. Shapiro, C. Weibel, D. Ferguson, M. L. Landry, and J. S. Kahn. 2005. Association between a novel human coronavirus and Kawasaki disease J. Inf. Dis. 191(4): 499-502. [html | pdf] |
Press Release [ERes] | Class discussion |
| Monday, February 7 |
First line of defense against infection | Bacterial Pathogenesis - Ch. 4 & 5 | HW#4 - Viruses [ERes] | Prof. Hamlett |
| Wednesday, February 9 |
Immune response & vaccines | Bacterial Pathogenesis - Ch. 6 & 7 Additional resources: "Understanding Vaccines" (NIAID) [pdf] "Understanding the Immune System" (NIAID) [pdf] "Prevention of Infectious Disease" (Ch. 8 in "Biotechnology & World Health", UT Austin) [pdf] |
HW#5 - Genome of your pathogen [ERes] | Prof. Hamlett |
| Friday, February 11 |
Paper | Gläser, R., J. Harder, H. Lange, J. Bartels, E. Christophers, and J.-M. Schröder. 2005. Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection. Nature Immunology 6(1): 57-64.[html | pdf] | Paper Analysis [MS Word] | Class discussion |
| Monday, February 14 |
Epidemiology | Epidemiology - Ch. 9 in Medical Microbiology | HW#6 - Immunology [ERes] | Prof. Hamlett |
| Wednesday, February 16 |
Factors in emergence of new diseases | Weiss, R. A., and A. J. McMichael. 2004. Social and environmental risk factors in the emergence of infectious diseases. Nature Medicine 10: S70 - S76. [html | pdf] | No assignment | Prof. Hamlett |
| Friday, February 18 |
Midterm Exam | |||
| Monday, February 21 |
||||
| Wednesday, February 23 | Ebola overview | Feldmann et al. 2003. TIMELINE: Ebola virus: from discovery to vaccine. Nat. Rev. Immunol. 3: 677-685. [html | pdf] | 3 Questions [MS Word] | Leila Cook |
| Friday, February 25 |
Ebola ecology | Leroy, E. M., et al. 2004. Multiple Ebola virus transmission events and rapid decline of Central African wildlife. Science 303: 387-390. [html | pdf] Related News articles from Science: Vogel, G. 2004. Ebola outbreaks may have had independent sources. Science 303: 298-299. [html | pdf] Vogel, G. 2003. Can great apes be saved From Ebola? Science 300: 1645. [html | pdf] |
Paper Analysis [MS Word] | Class discussion |
| Monday, February 28 |
Dengue overview | McBride, W. J., and H. Bielefeldt-Ohmann. 2000. Dengue viral infections; pathogenesis and epidemiology. Microbes Infect. 2(9): 1041-1050. [html | pdf] | 3 Questions [MS Word] | Sarah Rodenburg |
| Wednesday, March 2 |
Controlling dengue in resource-poor countries | Kay, B., and S. N. Vu. 2005. New strategy against Aedes aegypti in Vietnam. Lancet 365: 613-617. [html | pdf] | Dengue Questions [MS Word] | Class discussion |
| Friday, March 4 |
"Bioterror" (Nova) | -- | -- | |
| Monday, March 7 |
Schistosomiasis overview | Pearce, E. J., and A. S. MacDonald. 2002. The Immunobiology of schistosomiasis. Nat. Rev. Immunol. 2: 499-511. [ERes] | 3 Questions [MS Word] | Ranor Basa |
| Wednesday, March 9 |
HPV overview | Longworth, M. S., and L. A. Laimins. 2004. Pathogenesis of human papillomaviruses in differentiating epithelia. Microbiol. Mol. Biol. Rev. 68: 362-372. [ html | pdf] | 3 Questions [MS Word] | Adam Simning |
| Friday, March 11 |
Gerberding, J. L. 2004. REPORT TO CONGRESS: Prevention of Genital Human Papillomavirus Infection. Centers for Disease Control and Prevention. [pdf] For additional scientific information, you may wish to consult: Holmes, K. K., R. Levine, and M. Weaver. 2004. Effectiveness of condoms in preventing sexually transmitted infections. Bull World Health Organ. 82(6): 454-461. [pdf] |
HPV questions [MS Word] | Class discussion | |
| Monday, March 14 |
SPRING BREAK -- no class | |||
| Wednesday, March 16 |
||||
| Friday, March 18 |
||||
| Monday, March 21 |
Botulism overview | Ting, P. T., and A. Freiman. 2004. The story of Clostridium botulinum.: from food poisoning to Botox. Clin Med. 4(3): 258-261. [ERes] | 3 Questions [MS Word] | Ryan Murphy |
| Wednesday, March 23 |
How botulinum toxin gets from the digestive tract to the bloodstream | Fujinaga, Y., K. Inoue, S. Watanabe, K. Yokota, Y. Hirai, E. Nagamachi, and K. Oguma. 1997. The haemagglutinin of Clostridium botulinum type C progenitor toxin plays an essential role in binding of toxin to the epithelial cells of guinea pig small intestine, leading to the efficient absorption of the toxin. Microbiology. 143: 3841-3847. [pdf] | Paper Analysis [MS Word] | Class discussion |
| Friday, March 25 |
Cesar Chavez Day -- no class | |||
| Monday, March 28 |
BSE overview | Weissman, C. 2004. The state of the prion. Nat. Rev. Microbiol. 2: 863-871. [ERes] | 3 Questions [MS Word] | Alejo Enriquez |
| Wednesday, March 30 |
Legname, G., I. V. Baskakov,H-O B. Nguyen, D. Riesner,F. E. Cohen, S. J. DeArmond, and S. B. Prusiner. 2004. Synthetic Mammalian Prions. Science 305: 673-676. [html | pdf] You may also want to look at the related commentary: Couzin, J. 200. An end to the prion debate? Don't count on it. Science 305: 598. [html | pdf] |
Paper Analysis [MS Word] | Class discussion | |
| Friday, April 1 |
Tularemia overview | Larsson, P., et al. 2005. The complete genome sequence of Francisella tularensis, the causative agent of tularemia. Nat. Genet. 37: 153-159. [html | pdf] | 3 Questions [MS Word] | Margot Molander |
| Monday, April 4 |
Tularemia emergence - a case study | Avashia, S. B., et al. 2004. First reported prairie dog-to-human tularemia transmission, Texas, 2002. Emerg. Infect. Dis. 10(3). [html | pdf] Petersen, J.M., et al. Laboratory Analysis of Tularemia in Wild-Trapped, Commercially Traded Prairie Dogs, Texas, 2002. [html | pdf] A commentary in the same EID issue: Azad, A. F. Prairie Dog: Cuddly Pet or Trojan Horse? [html | pdf] |
Tularemia Questions [MS Word] | Class discussion |
| Wednesday, April 6 |
SARS overview | Clarke, T. 2003. SARS: What have we learned? Nature 424: 121-126. [html | pdf] For another recent review, see: Peiris, J. S., Y. Guan, and K. Y. Yuen. 2004. Severe acute respiratory syndrome. Nat. Med. 10(12 Suppl): S88-97. [html | pdf] |
3 Questions [MS Word] | Jennifer Ah-Kee |
| Friday, April 8 |
Translational frame-shifting in SARS | Baranov, P. V., C. M. Henderson, C. B.Anderson, R. F. Gesteland, J. F. Atkins, M. T. Howard. 2005. Programmed ribosomal frameshifting in decoding the SARS-CoV genome. Virology 332(2): 498-510. [html | pdf] | Paper Analysis [MS Word] | Class discussion |
| Monday, April 11 |
West Nile Virus overview | Campbell, G. L., A. A. Marfin, R. S. Lanciotti, and D. J. Gubler. 2002. West Nile virus. Lancet Infect. Dis. 2(9): 519-529. html| pdf] | 3 Questions [MS Word] | Jenny Jaskiewicz |
| Wednesday, April 13 |
Immune response to West Nile Virus | Diamond, M. S., E. M. Sitati, L. D. Friend, S. Higgs, B. Shrestha, and M. Engle. 2003. A critical role for induced IgM in the protection against West Nile Virus infection. J. Exp. Med. 198: 1853-1862. [html | pdf]] | Paper Analysis [MS Word] | Class discussion |
| Friday, April 15 |
Smallpox overview | Mahalingama, S., I. K. Damon, and B. A. Lidbury. 2004. 25 years since the eradication of smallpox: why poxvirus research is still relevant. Trends Immunol. 25: 636-639. [html | pdf] | 3 Questions [MS Word] | Ben Spector |
| Monday, April 18 | Engineering poxviruses | Jackson, R. J., A. J. Ramsay, C. D. Christensen, S. Beaton, D. F. Hall, and I. A. Ramshaw. 2001. Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox. J Virol. 75: 1205-1210. [html | pdf] See also this related editorial: Nowak, R. 2001. Disaster in the making: An engineered mouse virus leaves us one step away from the ultimate bioweapon. New Scientist 169: 4(2). [html] |
Paper Analysis [MS Word] | Class discussion |
| Wednesday, April 20 |
Anthrax overview | Bacterial Pathogenesis - Ch. 22 | 3 Questions [MS Word] | Doyle Yang |
| Friday, April 22 |
Investigation of anthrax releases | Read, T. D., S. L. Salzberg, M. Pop, M. Shumway, L. Umayam, L. Jiang, E., et al. 2002. Comparative genome sequencing for discovery of novel polymorphisms in Bacillus anthracis. Science 296: 2028-2033. [html | pdf] Meselson, M., J. Guillemin, M. Hugh-Jones, A. Langmuir, I. Popova; A. Shelokov, and O. Yampolskaya. 1994 The Sverdlovsk anthrax outbreak of 1979. Science 266: 1202-1208. [html | pdf | Fig 2 | Fig 3] Takahashi, H., P. Keim, A. F. Kaufmann, C. Keys, K. L. Smith, K. Taniguchi, et al. 2004. Bacillus anthracis incident, Kameido, Tokyo, 1993. Emerg. Infect. Dis. 10(1) html | pdf] |
No written assignment | Class discussion |
| Monday, April 25 |
Influenza | Palese, P. 2004. Influenza: old and new threats. Nat. Med. 10: S82-S87. [html | pdf] | Prof. H | |
| Wednesday, April 27 |
H5N1 Avian Flu | Li, K. S., et al. 2004. Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia. Nature 430(6996): 209-213. [html | pdf] Of interest, but not required reading: Avian Influenza: Assessing the Pandemic Threat. 2005. WHO. [pdf] |
Paper Analysis [MS Word] | Class discussion |
| 7 p.m. | Dr. Jay Levy, UCSF "The Social and Economic Threat of HIV/AIDS: How Does Science Face the Challenge?" McAlister Auditorium of Galileo Hall, HMC [Press Release] |
|||
| Friday, April 29 |
No Class | No assignment | ||
| Monday, May 2 |
Pertussis | Bacterial Pathogenesis - Ch. 17 | 3 Questions | Prof. H |
| Wednesday, May 4 |
Wrap-up | |||
Page last updated 25 April 2005 by Nancy Hamlett.
