Home | Syllabus | Schedule | Presentations
Biology 189Q
Molecular Mechanisms of Bacterial Pathogenesis		 Fall 2006
 

Schedule

Please note that the schedule and readings are subject to change.

Assignment: Each week, students (except the presenter) will turn in a short summary and questions based on the reading that includes the following components:

  1. What was the purpose of this investigation? Was there an hypothesis? If so, what?
  2. What prior knowledge led up to formulating the question or hypothesis?
  3. What was the general experimental approach?
  4. Which experiment was most important in addressing the question or hypothesis? What did they do and what did it show?
  5. How did this paper change our knowledge of bacterial pathogenesis? What do we know now that we didn't know before?
  6. What would be the logical next step? What would you do if you were going to continue research on this problem?
  7. Questions (at least 3) arising from the book chapter or journal article. They may be what, why, what if, or any other kind you can think of!
Date Topic Reading in
Salyers & Whitt		 Journal Article Presenter
Sept  4 Organizational meeting & introduction Ch. 1 -- Prof. Hamlett
Sept 11 Bacterial cell structure and pathogenesis Ch. 8 Goodman et al. 2004. A signaling network reciprocally regulates genes associated with acute infection and chronic persistence in Pseudomonas aeruginosa. Dev. Cell 7: 745-754. [html | pdf] Prof. Hamlett
Sept 18 Bacterial exotoxins Ch. 9 Koriazova and Montal. 2003. Translocation of botulinum neurotoxin light chain protease through the heavy chain channel. Nature Structural Biology 10: 13-18. [html | pdf] Emily
Sept 25 Non-specific host defenses Ch. 4 & 5 Gläser et al. 2005. Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection. Nature Immunology 6(1): 57-64. [html | pdf] Alejandra
Oct 2 Antibodies Ch. 6 & 7 Zhang et al. 2002. Enhanced immunogenicity of a genetic chimeric protein consisting of two virulence antigens of Streptococcus mutans and protection against infection. Inf. Imm. 70: 6779-6787. [html | pdf] Yumi
Oct 9 Cell-mediated immunity Ch. 6 Brockstedt et al. 2005. Killed but metabolically active microbes: a new vaccine paradigm for eliciting effector T-cell responses and protective immunity. Nat. Med. 11: 853-860. [html | pdf]

See also the following News & Views article:
Frankel. 2005. Vaccine wakes from the dead. Nat. Med. 11: 833-834. [html | pdf]		 Mark
Oct 16 Fall Break - no class
Oct 23 Antibiotics and antibiotic resistance Ch. 10 & 11 Katayama et al. 2000. A New Class of Genetic Element, Staphylococcus Cassette Chromosome mec, Encodes Methicillin Resistance in Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 44: 1549-1555. [html | pdf] Brad
Bugg et al. 1991. Identification of vancomycin resistance protein VanA as a D-alanine:D-alanine ligase of altered substrate specificity. Biochemistry 30: 2017-2021. [pdf] David
Oct 30 Cholera Ch. 25 Lencer and Tsai. 2003. The intracellular voyage of cholera toxin: going retro. Trends Biochem. Sci. 28(12): 639-635. [html | pdf] Alejandra
Nov  6 Legionella Ch. 20 Fernandez-Moreira et al. 2006. Membrane vesicles shed by Legionella pneumophila inhibit fusion of phagosomes with lysosomes. Infect. Immun. 74(6): 3285-3295. [html | pdf]

An interesting review (optional):
Roy and Tilney. 2002. The road less traveled: transport of Legionella to the endoplasmic reticulum. J. Cell Biol. 158(3): 415-419. [html | pdf]		 Mark
Nov 13 Plague Ch. 13 Marketon et al. 2006. Plague bacteria target immune cells during infection. Science 309: 1739-1741. [html | pdf]

Cornelis. 2002. Yersinia type III secretion: send in the effectors. J. Cell. Biol. 158: 401-408. [html | pdf]		 Yumi
Nov 20 Pathogenic E. coli Ch. 28 & 29 Tobe et al. 2006. An extensive repertoire of type III secretion effectors in Escherichia coli O157 and the role of lambdoid phages in their dissemination. Proc. Natl. Acad. Sci. USA 103(40): 14941-14946. [html | pdf] David
Nov 27 Anthrax Ch. 22 Mock and Mignot. 2003. Anthrax toxins and the host: a story of intimacy. Cell. Microbiol. 5: 15-23. [html | pdf]

Brittingham et al. 2005. Dendritic cells endocytose Bacillus anthracis spores: implications for anthrax pathogenesis. J. Immunol. 174: 5545-5552. [html | pdf]		 Brad
Dec  4 Tuberculosis Ch. 19 Boshoff et al. 2005. Tuberculosis -- metabolism and respiration in the absence of growth. Nat. Rev. Microbiol. 3: 70-80. [html | pdf]

Weber et al. 2000. Anaerobic nitrate reductase (narGHJI) activity of Mycobacterium bovis BCG in vitro and its contribution to virulence in immunodeficient mice. Mol. Microbiol. 35: 1017-1025. [html | pdf]		 Emily

 

Page last updated 2 December 2006 by Nancy Hamlett.
Home | Syllabus | Assignments | Presentations