| Date | Topic | iGenetics | Problems | Articles | Links |
|---|---|---|---|---|---|
| Jan 21 | Introduction | Ch 1 | -- | Berger, D. 1998. What is Science? MadScience Network:Science History [html] | · Icelandic Genetics · The Genetic Bubble · DNA Secrets & Lies · Salmonella Outbreak · DIY DNA Search for 'genetics' in NY Times articles |
| Jan 23 | Mendelian Genetics 1 | Ch 2 | PS#1: 1 iGenetics: 2.1, 2.3, 2.4, 2.6, 2.10 |
Mendel, G. 1865. Experiments in plant hybridization. Verhandlungen des naturforschenden Vereines in Brünn, Bd. IV für das Jahr 1865, Abhandlungen, 3-47. [html (English translation) | pdf (in German – facsimile of original)] Hartl., D.L., and D.J. Fairbanks. 2007. Mud sticks: On the alleged falsification of Mendel’s data. Genetics 175: 975-979. [html] |
Mendel Museum of Genetics |
| Jan 26 | Mendelian Genetics 2 | Ch 2 | PS#1: 9, 10 iGenetics: 2.2, 2.15, 2.16, 2.22, 2.26, 2.27, 2.29 |
FDA ruling on genetically engineered animals DNA from the Beginning: Classical Genetics Online Mendelian Inheritance in Man – try searching for ‘albinism’ or ‘Marfan’ |
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| Jan 28 | Mitosis and Meiosis | Ch 3 | PS#1: 3, 4, 5 iGenetics: 3.15, 3.19, 3.20, 3.30 |
American Society for Cell Biology Mitosis and meiosis videos and images | |
| Jan 30 | Chromosomal Basis of Heredity 1 | Ch 3 | PS#1: 7, 8, 11 iGenetics: 3.23, 3.25, 3.28 |
Sutton, W. S. 1902. On the morphology of the chromosome group in Brachystola magna. Biol. Bull. 4: 24-39. [pdf] Sutton, W.S. 1903. The chromosomes in heredity. Biol. Bull. 4: 231-251. [pdf] |
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| Feb 2 | Chromosomal Basis of Heredity 2 | Ch 3 | iGenetics: 3.39, 3.42, 3.43, 3.44, 3.45 |
Bridges, C.B. 1916. Non-disjunction as proof of the chromosome theory of heredity (part 1). Genetics B, 1: 1-52. [pdf] Bridges, C.B. 1916. Non-disjunction as proof of the chromosome theory of heredity (part 2). Genetics B, 1: 107-163. [pdf] Barr, M.L., and E.G. Bertram. 1949. A morphological distinction between neurones of the male and female, and the behaviour of the nucleolar satellite during accelerated nucleoprotein synthesis. Nature 163: 676-677. [pdf] |
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| Feb 4 | Extensions of Mendelian Genetics |
Ch 4 | PS#1: 2, 6 PS#2: 1, 4 iGenetics: 4.6, 4.10, 4.16, 4.18, 4.25 |
Bowling, A.T. 1994. Dominant inheritance of overo spotting in paint horses. J. Hered. 85: 222-224. [pdf] | |
| Feb 6 | Epistasis | Ch 4 | PS#1: ‘Hard Problem’ PS#2: 1, 2, 3, 4 iGenetics: 4.19, 4.20, 4.23, 4.27 |
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| Feb 9 | Linkage | Ch 6 | PS#2: 5, 6, 7 iGenetics: 6.2, 6.5 |
Creighton, H.B., and McClintock, B. 1931. A correlation of cytological and genetical crossing-over in Zea mays. PNAS 17: 492-497. [pdf] | |
| Feb 11 | Gene Mapping | Ch 6 | PS#3: 1, 2, 3, 4 iGenetics: 6.11, 6.14, 6.21, 6.26 |
Sturtevant, A.H. 1913. The linear arrangement of six sex-linked factors in Drosophila, as shown by their mode of association. J. Exp. Biol. 14: 43-59. [pdf] | |
| Feb 13 | Midterm Exam 1 |
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| Feb 16 | Cytogenetics 1 | Ch 8 | PS#4: 1, 3 iGenetics: 8.11 |
Ried, T., E. Schrock, Y. Ning, and J. Wienberg. 1998. Chromosome painting: a useful art. Human Mol Genetics 7: 1619-1626. [html | pdf] | What Can Our Chromosomes Tell Us – Genetic Science Learning Center, University of Utah |
| Feb 18 | Cytogenetics 2 | Ch 8 | PS#4: 2, 4 iGenetics: 8.9, 8.15, 8.17, 8.24, 8.28 |
Muggli, M.E., J.O Ebbert, C. Robertson, and R.D Hurt. Waking a sleeping giant: The tobacco industry's response to the Polonium-210 issue. Amer J Pub Health 98: 1643-1650. [html | pdf] | |
| Feb 20 | Bacterial Genetics Introduction | Ch 9 | |||
| Feb 23 | Bacterial Genetics 2 | Ch 9 | PS#4: 6, 7, 10 iGenetics: 9.2, 9.3, 9.22 |
Lederberg, J., and E.M. Lederberg. 1952. Replica plating and indirect selection of bacterial mutants. J. Bacteriol. 63: 399-406. [pdf] Lederberg, J., and E.L. Tatum. 1946. Gene recombination in E. coli. Nature 158: 558. [pdf] Davis, B.D. 1950. Nonfilterability of the agents of genetic recombination in Escherichia coli. J. Bacteriol. 64: 506-509. [pdf] |
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| Feb 25 | Bacterial Genetics 3 | Ch 9 | PS#4: 8 iGenetics: 9.1, 9.6, 9.7 |
Zinder, N.D., and J. Lederberg. 1952. Genetic exchange in Salmonella. Nature 158: 558. J. Bacteriol. 60: 679-699. [pdf] | |
| Feb 27 | Phage Genetics 1 | Ch 9 | PS#4: 9 iGenetics: 9.8, 9.10, 9.11, 9.13, 9.20 |
DNA from the Beginning: Bacteria and viruses have DNA too – try the problem! | |
| Mar 2 | Phage Genetics 2 & DNA | Ch 10 | PS#4: 5 PS#5: 1, 3 iGenetics: 10.10, 10.12, 10.16, 10.17, 10.24, 10.25 |
Benzer, S. 1961. On the topography of the genetic fine structure. PNAS 47: 403-426. [pdf] Avery, O.T., C.M. McLeod, and M. McCarty. 1944. Studies on the chemical nature of the cubstance inducing transformation of pneumococcal types: Induction of transformation by a desoxyribonucleic acid fraction isolated from Pneumococcus Type III. J. Exp. Med. 79: 137-158. [pdf] Watson, J.D., and F.H.C. Crick. 1953. A structure for deoxyribose nucleic acid. Nature 171: 737-738. [pdf] |
DNA from the Beginning: A Gene is Made of DNA |
| Mar 4 | DNA Replication 1 | Ch 11 | PS#5: 2, 4 iGenetics: 11.2, 11.5, 11.6 |
Meselson, M., and F.W. Stahl. 1958. The replication of DNA in Escherichia coli. PNAS 44: 671-682. [pdf] Lehman, I.R., M.J. Bessman, E.S. Simms, A. and A. Kornberg. 1958. Enzymatic synthesis of deoxyribonucleic acid. I. Preparation of aubstrates and partial purification of an enzyme from Escherichia coli J. Biol. Chem. 233: 163-170. [pdf] Bessman, M.J., I.R.Lehman, E.S. Simms, A. and A. Kornberg. 1958. Enzymatic synthesis of deoxyribonucleic acid. II. General properties of the reaction. J. Biol. Chem. 233: 163-170. [pdf] |
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| Mar 5 | DNA Replication 2 | Ch 11 | iGenetics: 11.11, 11.14, 11.17 | Okazaki, R. T. Okazaki, K. Sakabe, K. Sugimoto, and A. Sugino. 1968. Mechanism of DNA chain growth. I. Possible discontinuity and unusual secondary structure of newly sythesized chains. PNAS 59: 598-605. [pdf] Sugimoto, K., T. Okazaki, and R. Okazaki. 1968. Mechanism of DNA chain growth. II. Accumulation of newly synthesized short chains in E. coli infected with ligase-defective T4 phages. PNAS 60: 1356-1362. [pdf] de Lucia, P., and J. Cairns 1969. Isolation of an E. coli strain with a mutation affecting DNA Polymerase. Nature 224: [pdf] |
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| Mar 9 | DNA Replication 3 | Ch 11, Ch 16: 441-447 | iGenetics: 11.23, 11.28, 16.36, 16.37, 16.40 | Garrod, Archibald E. 1902. The incidence of alkaptonuria: A study in chemical individuality. Lancet 2: 1616-1620. [pdf] Beadle, G.W., and E.L. Tatum. 1941. Genetic control of biochemical reactions in Neurospora. PNAS 27:499-506. [pdf] |
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| Mar 11 | Midterm Exam 2 |
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| Mar 13 | Gene Function | Ch 12 | PS#4: 5 iGenetics: 12.4, 12.16, 12.17, 12.19 |
Garrod, Archibald E. 1902. The incidence of alkaptonuria: A study in chemical individuality. Lancet 2: 1616-1620. [pdf] Beadle, G.W., and E.L. Tatum. 1941. Genetic control of biochemical reactions in Neurospora. PNAS 27:499-506. [pdf] |
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| Mar 16–20 | Spring Vacation |
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| Mar 23 | Transcription 1 | Ch 13 | iGenetics: 13.1, 13.7, 13.8, 13.9 | ||
| Mar 25 | Transcription 2 | Ch 13 | PS#6: 1 iGenetics: 13.3, 13.4, 13.10, 13.22, 13.23 |
Chow, L.T., R.E. Gelinas, T.R. Broker, and R.J. Roberts. 1977. An amazing sequence arrangement at the 5' ends of adenovirus 2 messenger RNA. Cell 12: 1-8. [pdf] Berget, S.M., C. Moore, and P.A. Sharp. 1977. Spliced segments at the 5' terminus of adenovirus 2 Late mRNA. PNAS 74: 3171-3175. [pdf] |
Order your own RNA Tie from DNAStuff! |
| Mar 26 | Cesar Chavez Day (no class) |
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| Mar 30 | Genetic Code 1 | Ch 14 | PS#6: 2 iGenetics: 14.18 |
Crick, F.H.C., L. Barnett, S. Brenner, and R.J. Watts-Tobin. 1961. General nature of the genetic code for proteins. Nature 192: 1227-1232. [pdf] Hayes, B. 1998. The invention of the genetic code. Amer. Sci. 86: 8-14. [html | pdf] |
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| Apr 1 | Genetic Code 2 | Ch 14 | PS#7.5: 1 iGenetics: 14.17, 14.24, 14.26 |
Nirenberg, M.W., and J.H. Matthaei. 1961. The dependence of cell-free protein synthesis in E. coli upon naturally occurring or synthetic polyribonucleotides. PNAS 47: 1588-1602. [pdf] | DNA from the Beginning: RNA is an intermediary between DNA and protein Video interviews with Marshall Nirenberg and Sydney Brenner at Cold Spring Harbor’s DNA interactive - select Code > Reading the Code > Players |
| Apr 3 | Translation | Ch 14 | PS#6: 3 PS#6.5: 1, 2, 3 PS#7: 1 PS#7.5: 2 iGenetics: 14.10, 14.14, 14.15, 14.27, 14.30 |
Paul Berg’s Protein Synthesis Movie on YouTube. | |
| Apr 6 | Proteins & Mutations 1 | Ch 14 (355-359), Ch 15 (to p397) | PS#8: 1 iGenetics: 14.3, 15.5, 15.6, 15.9, 15.13 |
Anfinsen, C.B., and E. Haber. 1961. Studies on the reduction and re-formation of protein disulfide bonds. J. Biol. Chem. 236: 1361-1363. [pdf] | Christian Anfinsen’s Nobel Prize Lecture [pdf] |
| Apr 8 | Mutation & Repair 2 | Ch 15 (to p397) | PS#8: 2, 3, 4, 5 iGenetics: 15.8, 15.15, 15.18, 15.27, 15.28 |
Muzyczka, N., R.L. Poland, and M.J. Bessman. 1972. Studies on the biochemical basis of mutation. I. A comparison of the deoxyribonucleic acid polymerases of mutator, antimutator, and wild type strains of bacteriophage T4. J. Biol. Chem. 247: 7116-7122. [pdf] | |
| Apr 10 | Mutation 3 | Ch 15 (to p397); Ch 19 | PS#7: 4, 6 iGenetics: 15.27, 15.28 |
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| Apr 13 | Regulation 1 | Ch 19 | PS#8: 4, >PS#8.5: 1 iGenetics: 19.5, 19.9, 19.11, 19.12 |
Pardee, A., F. Jacob, and J. Monod. 1959. The genetic control and cytoplasmic expression of ‘inducibility’ in the synthesis of beta-galactosidase by E. coli. J. Mol. Biol. I: 165-177. [pdf] | |
| Apr 15 | Regulation 2 | Ch 20 | PS#8: 4 iGenetics: 19.14, 19.16, 19.17, 19.19 |
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| Apr 17 | Regulation 3 | Ch 20 | iGenetics: 20.6, 20.17 | Gillies, S.D., S.L. Morrison, V.T. Oi, and S. Tonegawa. 1983. A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene. Cell. 33: 717–728. [pdf] | |
| Apr 20 | Quantitative Genetics 1 | Ch 5 | PS#9: 2, 3, 4, 5 iGenetics: 5.3, 5.4, 5.14 |
Introduction to Quantitative Genetics, North Dakota State University | |
| Apr 22 | Midterm Exam 3 |
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| Apr 24 | Quantitative Genetics 2 | Ch 5 | PS#9: 1, 6 iGenetics: 5.22, 5.26 |
Illinois Maize Breeding and Genetics Laboratory | |
| Apr 27 | Population Genetics 1 | Ch 24 | PS#10: 1 iGenetics: 24.1, 24.4, 24.5, 24.8, 24.30, 24.31 |
Hardy, G.H. 1908. Mendelian proportions in a mixed population. Science 28: 49-50. [pdf] Woolf, C.M., and F.C. Dukepoo. 1969. Hopi Indians, inbreeding, and albinism. Science 164: 30-37. [html | pdf] |
Crow, J.F. 1999. Hardy, Weinberg, and language impediments. Genetics 152: 821-825. [html | pdf] Holden, C. 1992. Minority survivors tell their tales. Science 58: 1204-1206. [html | pdf] |
| Apr 29 | Population Genetics 2 | Ch 24 | PS#10: 1, 6 iGenetics: 24.23, 24.25, 24.27 |
Galvani, A.P., and J. Novembre. 2005. The evolutionary history of the CCR5-Delta32 HIV-resistance mutation. Microb. Infect. 7: 302-309.
[pdf] Galvani, A.P., and M. Slatkin. 2004. Evaluating plague and smallpox as historical selective pressures for the CCR5-Δ32 HIV-resistance allele. PNAS 100: 15276-15279. [html | pdf] |
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| May 1 | Population Genetics 3 | Ch 24 | PS#10: 2, 3, 4 iGenetics: 24.16, 24.20, 24.33 |
Westemeier, R.L., et al. 1998. Tracking the long-term decline and recovery of an isolated population. Science 282: 1695-1698. [html | pdf] Bellinger, R., et al. 2003. Loss of genetic variation in greater prairie chickens following a population bottleneck in Wisconsin, USA. Cons. Biol. 17: 717-724. [pdf] |
Simulation Server at the Dolan DNA Learning Center. |
| May 4 | Population Genetics 4 | Ch 24 | PS#10: 5 iGenetics: 24.13, 24.34 |
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| May 6 | Concluding Discussion | ||||
| May 14 Thursday |
Final Exam, 9:00 am |
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Page last updated 6 May 2009 by Nancy Hamlett.