Dan O'Leary

   Carnegie Professor of Chemistry

   B.A., 1986, Linfield College

   Ph.D, 1991, University of California, Los Angeles

   NSF Postdoctoral Fellow, 1991-1994, Harvard University

   Email: doleary@pomona.edu

   Tel: (909) 621-8444

   Office: Seaver Chemistry Laboratory, Room 208

Recent Courses:

Organic Chemistry (110a/b)      NMR Spectroscopy (172)

Research Interests:

Organic Chemistry; Nuclear Magnetic Resonance. Development of isotopic perturbation methods for detecting intramolecular hydrogen bonds; synthesis and study of chemically modified biological structures.

Recent Publications (student researchers denoted by year of graduation)

Conformations of N-Heterocyclic Carbene Ligands in Ruthenium Complexes Relevant to Olefin Metathesis.  Stewart, I. C.; Benitez, D.; O’Leary, D. J.; Thatchouk, E.; Day, M. W.; Goddard, W. A.; Grubbs, R. H.  J. Am. Chem. Soc., 2009, 131, 1931-1938.

Conformational Analysis of a Covalently Linked Watson-Crick Base Pair Model.  Jensen, E. A. (’03), Allen, B. D. (’03), Kishi, Y. K.; O’Leary, D. J.  Bioorganic  and Medicinal Chemistry Letters, 2008, 18, 5884-5887.

Vicinal Deuterium Perturbations on Hydrogen NMR Chemical Shifts in Cyclohexanes.  O’Leary, D. J.; Allis, D. J.; Hudson, B. S.; James, S.; Morgera, K. B.; Baldwin, J. E. J. Am. Chem. Soc. 2008, 130, 13659-13663.

Ruthenium-Olefin Complexes: Effect of Ligand Variation upon Geometry.  Anderson, D. R.; O’Leary, D. J.; Grubbs, R. H.  Chemistry: A European Journal, 2008, 14, 7536-7544.

Synthesis and Reactivity of Olefin Metathesis Catalysts Bearing Cyclic (Alkyl)(Amino)Carbenes.  Anderson, D. R., Lavallo, V., O'Leary, D. J., Bertrand, G., Grubbs, R. H. Angewandte Chemie International Edition, 2007, 46, 7262-7265.  

Elective and capstone undergraduate experiences in NMR spectroscopy. A curriculum that prepares students for independent research in magnetic resonance.  O'Leary, Daniel J.; Steinmetz, Wayne E.  ACS Symposium Series  (2007),  969(Modern NMR Spectroscopy in Education),  36-47.

Facile and E-Selective Ring-Closing Metathesis Reactions in 310-Helical Peptides: a 3D-Structural Study.  Boal, A. K. (’02); Guryanov, I.; Moretto, A.; Crisma, M.; Lanni, E. (’06); Toniolo, C.; Grubbs, R. H.; O’Leary, D. J.  Journal of the American Chemical Society, 2007, 129, 6986-6987.

NMR Detection of Intramolecular OH/OH Hydrogen Bond Networks: An Approach Using Isotopic Perturbation and Hydrogen Bond Mediated OH---OH J-Coupling.  Anderson, C. E.; Pickrell, A. J.(’05); Sperry, S. L.(’05); Vasquez, Jr., T. E.(’02); Custer, T. G.(’97); Fierman, M. B.(’00); Lazar, D. C.(’07); Brown, Z. W.(’07); Iskenderian, W. S.(’04); Hickstein, D. D.(’07); O’Leary, D. J.  Heterocycles, 2007, 72, 469-495.

Qualitative and Quantitative Measurements of Hydrogen Bond-Mediated Scalar Couplings in Acyclic 1,3-Diols. Loening, N. M.; Anderson, C. E.; Iskenderian, W. S.(’04); Anderson, C. D. Rychnovsky, S. D.; Barfield, M.; O’Leary, D. J. Org. Lett., 2006, 8, 5321-5323.

Model Compounds of Ruthenium-Alkene Intermediates in Olefin Metathesis Reactions.  Anderson, D. R.; Hickstein, D. D.(’07); O’Leary, D. J.; Grubbs, R. H.  J. Am. Chem. Soc., 2006, 128, 8386-8387.

Enantioselective Photocycloaddition Mediated by Chiral Bronsted Acids: Asymmetric Synthesis of the Rocaglamides.  Gerard, B.; Sangji, S.(’08); O’Leary, D. J.; Porco, J. A., Jr.  J. Am. Chem. Soc., 2006, 128, 7754-7755.

Direct Assignment of the Relative Configuration in Acyclic 1,3-Diols by 1H NMR Spectroscopy
Anderson, C. E.; Britt, D. K.(’05); Sangji, S.(’08); O'Leary, D. J.; Anderson, C. D.; Rychnovsky, S. D.; Org. Lett., 2005, 7, 5721-5723.

An Isosparteine Derivative for Stereochemical Assignment of Stereogenic (Chiral) Methyl Groups using Tritium NMR: Theory and Experiment.  Allen, B. D.(’03); Cintrat, J. C.; Faucher, N.; Berthault, P.; Rousseau, B.; O’Leary, D. J.  J. Am. Chem. Soc. 2005, 127, 412-420.