Math 150 – Fall 2010

Statistics for Clinical Trials

Jo Hardin

 

Homework Assignments:

 

Text: Regression Methods in Biostatistics, Vittinghoff, Glidden, Shiboski, and McCulloch

Text website:  http://www.epibiostat.ucsf.edu/biostat/vgsm/

 

Supplement: Stat 2 Labs by Shonda Kuiper

Website: http://web.grinnell.edu/individuals/kuipers/stat2labs/

You:  all the supplemental materials are on Sakai

 

 

Due Date

Chapter

Topic

Problems:

Handout / R code

Lab #0

Thurs 9/2

 

 

R tutorial (see course website, nothing due)

 

Lab #1

Tues 9/7

K2

t-test

Activities 1 – 8, Rcode

 

HW #1

Thurs 9/9

2, 3.1

 

2.1, 2.4, 3.2, K2.34 (pg 25, actually 96 species)

 

Lab #2

Tues 9/14

K2

vs. lin reg

Activities (9) – (15)

Linear Regression Code

HW #2

Thurs 9/16

See handout

Regression

See handout and data

 

Lab #3

Tues 9/21

K6

Contingency tables

Activities 32-35 (plus identifying variables)

(See Sakai for Chapter 6 of Stat2Labs)

 

HW #3

No HW

 

 

 

 

Lab #4

Tues 9/28

K7(1)

Logistic regression

Activities 1-4 (data and chapter 7 on Sakai)

 

HW #4

Thurs 9/30

 

Contingency tables

See handout

 

Lab #5

No lab

 

 

 

 

HW #5

Thurs 10/7

6

Logistic regression

See handout and data   SOLUTIONS

 

HW #6

Tues 10/12

6

Logistic regression

See handout and data SOLUTIONS

 

 

Thurs 10/14

 

Exam 1

 

 

 

Fall Break

 

 

 

Simpson’s Paradox

Lab #7 (labeled for consistency???)

Thurs 10/21

K7(2)

Multiple logistic regression

Activities 1-4 in the second logistic regression pdf

Multiple explanatory variables – logistic regression

 

 

 

 

 

Adding and dropping variables

HW #7 (I have no idea which HW # to use…)

Thurs 10/28

 

 

Book: 4.11, 6.4, 6.5 + one more

 

 

Tues 11/2

 

Read the article:

(nothing to turn in)

J. Ioannidis, Why most published research findings are false.  PLoS Medicine, 2. e124 2005.

ROC curves

HW #8

Thurs 11/4

 

 

assignment  /  data (dmd.csv)

 

Lab #9

Tues 11/9

K9

 

Activities (1) – (3)  (chapter 9 on Sakai)

 

HW #9

Thurs 11/11

 

 

assignment (see ROC handout)

 

 

 

 

 

 

 

Complete draft

Thurs 11/18

 

 

Complete draft of research paper due

 

HW #10

Tues 11/23

 

 

assignment (mostly from chapter 9 of Stat2Labs) / data (firstdrink.csv)

Kaplan-Meier curves & Logrank Test Rcode

 

Thurs

Thanksgiving

 

 

 

 

 

Tues 11/30

 

 

 

 

 

Thurs 12/2

 

 

Final research paper due

 

HW # 11

Tues 12/7

 

 

assignment / data (BreastCancer.csv)

 

 

 

 

 

 

 

 

Thurs 12/16

 

 

Take home final due (9am?) liver cirrhosis data

 

 

 

 

 

 

 

 

 

Research paper assignment

Thurs 11/4: topic & background

Thurs 11/18: completed draft w/statistical analyses

Thurs 12/2: final version