Matthew H. Sazinsky Assistant Professor of Chemistry, Pomona College

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Peer Reviewed Publications

UNDERGRADUATE AUTHORS ARE UNDERLINED

Sazinsky, M. H, LeMoine, B., Orofino, M., Davydov, R., Bencze, K., Mandal, A. K., Stemmler, T. L., Hoffman, B. M., Argüello, J. M., Rosenzweig, A. C. Characterization and Structure of a Novel Zn²⁺ and [2Fe-2S]-Containing Copper Chaperone from Archaeoglobus fulgidus. J. Biol. Chem. 2007, 282, 25950-25959.

Sazinsky, M. H., Dunten, P., McCormick, M. S., Di Donato, A., Lippard, S. J. X-ray Structure of a Hydroxylase-Effector Protein Complex from a Hydrocarbon Oxidizing Multicomponent Monoxygenase. Biochemistry. 2006, 45, 15392-15404.

Rosenzweig, A. C. Sazinsky, M. H. Structural insights into dioxygen-activating copper enzymes. Curr. Opin. Struct. Biol. 2006, 16, 729-735.

McCormick, M. S., Sazinsky, M. H., Condon K. L., Lippard, S. J. X-ray Structure of Manganese(II) Reconstituted Toluene /o-Xylene Monooxygenase Hydroxylase, J. Am. Chem. Soc. 2006, 128, 15108-15110.

Sazinsky, M. H., Lippard, S. J. Correlating Structure with Function in Bacterial Multicomponent Monooxygenases and Related Diiron Proteins. Acc. Chem. Res. 2006, 39, 556-566.

Sazinsky, M. H., Agarwal, S., Argüello, J. M., Rosenzweig A. C., Structure of the Actuator Domain from the Archaeoglobus fulgidus Cu⁺-ATPase. Biochemistry. 2006, 45, 9949-9955.

Sazinsky, M. H., Mandal, A. K., Argüello, J. M., Rosenzweig, A. C. Structure and Characterization of the ATP Binding Domain from the Archaeoglobus fulgidus Copper Transporting P1-Type ATPase CopA. J. Biol. Chem. 2006, 281, 11161-11166.

Jackson Rudd, D. Sazinsky, M. H., Lippard, S. J., Hedman, B., Hodgson, K. O. X-ray Absorption Spectroscopic Study of the Reduced Hydroxylases of Methane Monooxygenase and Toluene/o-Xylene Monooxygenase: Differences in Active Site Structure and Effects of the Coupling Proteins MMOB and ToMOD. Inorg. Chem., 2005, 44, 4546-4554.

Lu, S., Sazinsky, M. H., Whittaker, J. W., Lippard, S. J.; Moenne-Loccoz, P. Fourier Transform Infrared Characterization of the Azido Complex of Methane Monooxygenase Hydroxylase from Methylococcus capsulatus (Bath). J. Am. Chem. Soc., 2005, 127, 4148-4149.

Sazinsky, M. H., Lippard, S. J. Product Bound Structures of the Soluble Methane Monooxygenase Hydroxylase from Methylococcus capsulatus (Bath): Protein Motion in the a-Subunit. J. Am. Chem. Soc., 2005, 127, 5814-5825.

Sazinsky, M. H., Merkx, M., Tang, S., Lippard, S. J. Coordination Chemistry at an Enzyme Active Site; Preparation and X-ray Structures of Metal-free, Dicobalt and Dimanganese Forms of Soluble Methane Monooxygenase Hydroxylase. Biochemistry. 2005, 43, 4579-4589

Jackson-Rudd, D., Sazinsky, M. H., Merkx, M., Lippard, S. J., Hedman, B., Hodgson, K. O. Determination by X-ray Absorption Spectroscopy of the Fe-Fe Separation in the Oxidized Form of the Hydroxylase of Methane Monooxygenase Alone and in the Presence of MMOD. Inorg. Chem. 2004, 43, 4579-4589.

Sazinsky, M. H., Bard, J., DiDonato, A., Lippard, S. J. Crystal Structure of the Toluene/ o-Xylene Monooxygenase Hydroxylase from Pseudomonas stutzeri OX1: Insight into the Substrate Specificity, Substrate Channeling and Active Site Tuning of Multicomponent Monooxygenases J. Biol. Chem. 2004, 279, 10600-10610.

MacArthur, R., Sazinsky, M. H., Kuhne, H., Whittington, D. A., Lippard, S. J., Brudvig, G. Component B Binding to the Soluble Methane Monooxygenase Hydroxylase by Saturation-Recovery EPR Spectroscopy of Spin-Labeled MMOB. J. Am. Chem. Soc. 2002, 124, 13392-13393.

Merkx, M. Kopp, D. A., Sazinsky, M. H., Muller, J., Blazyk, J. B., Lippard, S. J. Dioxygen Activation and Methane Hydroxylation by Soluble Methane Monooxygenase: A Tale of Two Irons and Three Proteins. Angew Chem. Int. Edit. 2001, 40, 2782-2807.

Whittington, D. A., Sazinsky, M. H., and Lippard, S. J. X-ray Crystal Structure of Alcohol Products Bound at the Active Site of Soluble Methane Monooxygenase Hydroxylase. J. Am. Chem. Soc. 2001, 123, 1794-1795.

Jaffe, E. K., Volin, M., Bronson-Mullins, C. R., Dunbrack, D. L., Kervinen, J., Martins, J., Quinlan, J. F., Sazinsky, M. H., Steinhouse, E. M., Yeung, A. T. An Artificial Gene for Human Porphobilinogen Synthase Allows Comparison of an Allelic Variation Implicated in Susceptibility to Lead Poisoning. J. Biol. Chem. 2000, 275, 2619-2626.

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